Women's Journal — Health, Beauty, Fitness & Lifestyle

A small UCLA Health case series found that 20 menopausal women reported improvements in brain fog and several cognitive symptoms after 12 months of customized estriol and progesterone treatment. The findings add preliminary evidence to research on menopause brain fog, but the uncontrolled study cannot show that the hormone regimen caused the changes. Key Takeaways The study followed 20 menopausal women with a mean age of 53.5 for 12 months. Participants received customized oral estriol and progesterone treatment and reported improvements in six cognitive areas, including brain fog and memory. The human findings were based on self-reported symptoms measured before treatment and again at 12 months. The study had no placebo group, randomization, or untreated comparison group, preventing researchers from establishing causation. Researchers called for larger placebo-controlled trials using standardized cognitive testing and brain imaging. UCLA Study Finds Improvement in Self-Reported Cognitive Symptoms UCLA researchers reported statistically significant improvements in menopause brain fog and several related cognitive complaints after 20 women received customized estriol and progesterone treatment for 12 months. Published September 1, 2026, in Scientific Reports, the observational case series included menopausal women with a mean age of 53.5. Participants rated their cognitive symptoms before treatment and again at